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Batch SVA-0417

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Weight & Metabolic · GLP-1 / GIP / glucagon triple agonist

Retatrutide UK

Name: Retatrutide
Brand: Sova Peptides
Availability: InStock

Retatrutide supplied as a lyophilised powder for reconstitution. Reference-grade purity, mass-spec confirmed identity, and a batch-linked Certificate of Analysis with every order.

In stock · UK·Ships today before 3pm

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1 vial

Base

3+ vials

−10%

6+ vials

−18%

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About the compound

What is retatrutide?

Retatrutide (research code LY3437943) is a synthetic, single-molecule peptide that acts as a triple agonist at three metabolic receptors: GLP-1, GIP and glucagon. Originally developed by Eli Lilly, it has become one of the most closely watched compounds in metabolic research, investigated in clinical trials for its effects on body weight and glucose regulation. Sova supplies retatrutide as a lyophilised, reference-grade reference standard for laboratory research use only.

What sets retatrutide apart from first-generation incretin research compounds is that three-way agonism. Rather than engaging a single receptor, it combines the incretin activity of GLP-1 and GIP with the energy-expenditure signalling of glucagon in one sequence. That combination is why researchers looking for a triple-agonist reference standard seek a verified retatrutide UK source with real analytical data, rather than an unverified import of unknown identity.

Retatrutide first drew wide interest when phase-2 clinical trial data placed it among the most closely studied of the emerging triple-agonist compounds. In the research literature it is examined for its influence on body weight, glucose handling and lipid metabolism. Sova's role is narrow and deliberate: to supply a correctly identified, high-purity reference standard so that laboratory work is done on the right molecule.

For UK-based researchers, provenance matters. An unverified overseas import can arrive with uncertain identity, a degraded peptide, or no analytical data at all. A verified retatrutide UK supplier ships from domestic stock with a Certificate of Analysis tied to the specific batch — no customs delay, and no guesswork about what is actually in the vial.

Every Sova retatrutide batch is analysed by reverse-phase HPLC for purity and ESI mass spectrometry for identity, and ships with a batch-linked Certificate of Analysis. No blanket purity claims, no borrowed lab names — just the certificate for the exact vial in your hand, verifiable from its batch code.

Mechanism

One molecule, three receptors.

Retatrutide's defining feature is that a single peptide sequence engages three receptors at once. Each arm contributes a distinct signalling pathway studied in metabolic research, and it is the combination — not any one receptor — that makes retatrutide a distinct reference compound.

GLP-1

Incretin, arm one

The receptor central to glucose-dependent insulin signalling and satiety pathways studied across metabolic research.

GIP

Incretin, arm two

The second incretin receptor; co-agonism with GLP-1 is studied for additive effects over single-incretin compounds.

Glucagon

Energy expenditure

Adds an energy-expenditure signalling arm — the axis that separates a triple agonist from dual-incretin peptides.

Comparison

How retatrutide compares.

Retatrutide belongs to the incretin-agonist family, but it sits a step beyond the compounds most researchers will already know. The practical difference is simply how many receptors a single molecule engages:

Compound	Receptor targets	Class
Semaglutide	GLP-1	Mono-agonist
Tirzepatide	GLP-1 + GIP	Dual agonist
Retatrutide	GLP-1 + GIP + glucagon	Triple agonist

That third arm — glucagon-receptor agonism — is what distinguishes retatrutide as a research object, adding an energy-expenditure signalling pathway that dual-incretin compounds do not engage. Sova stocks retatrutide and the amylin analogue cagrilintide; it does not supply semaglutide or tirzepatide.

Verification

Two tests, one certificate.

Every batch of Sova retatrutide is analysed twice: reverse-phase HPLC establishes purity, and electrospray-ionisation mass spectrometry confirms the molecular identity against retatrutide's expected mass of 4731.29 Da. The result is issued as a Certificate of Analysis carrying the batch code printed on the vial, so the data always matches the exact material you receive — nothing generic, and no third-party lab named that did not run the sample.

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Specification

Read the vial.

Compound: Retatrutide
CAS number: 2381089-83-2
Molecular formula: C₂₂₆H₃₅₆N₆₄O₆₉
Molecular weight: 4731.29 g/mol
Purity (HPLC): 99.4%
Identity: Confirmed by ESI-MS
Sequence: H-Y-Aib-EGT-α-MeF-TSDYSIαMeLLDKKAQ-Aib-AFIEYLLEGGPSSGAPPPS-NH₂ (γGlu-C20 diacid at K20)
Form: Lyophilised powder, sterile-filtered
Storage: Store lyophilised at ≤ −20 °C. Reconstituted: 2–8 °C, use within 28 days.
Tested by: Independent UK laboratory
Batch: SVA-0417

Reconstitution guidance

Handled like a lab reagent.

Reconstitute with bacteriostatic water. Draw slowly against the vial wall — do not agitate. Swirl gently until fully dissolved. Store reconstituted vials at 2–8 °C and use within 28 days. Full protocol on the Certificate of Analysis.

Research use only · Not for human or veterinary use

Example dilutions · 10 mg vial

BAC water	Concentration	Per 0.05 ml
1.0 ml	10 mg / ml	0.50 mg
2.0 ml	5 mg / ml	0.25 mg
3.0 ml	3.33 mg / ml	0.17 mg
5.0 ml	2 mg / ml	0.10 mg

Concentration reference only — not a dosing schedule.

FAQ

Retatrutide, answered.

What is retatrutide?

Retatrutide (LY3437943) is a synthetic peptide that acts as a triple agonist of the GLP-1, GIP and glucagon receptors. Sova supplies it as a lyophilised reference-grade compound for in-vitro and laboratory research only.

Is retatrutide legal to buy in the UK?

Sova sells retatrutide strictly as a research chemical for laboratory research use only. It is not a licensed medicine and is not sold for human or veterinary use. Purchases are for qualified researchers aged 18 or over.

Where can I buy retatrutide in the UK?

Sova Peptides supplies retatrutide from UK stock with same-day dispatch before 3pm and a batch-linked Certificate of Analysis. It is sold strictly for laboratory research use to qualified researchers aged 18 or over.

What makes retatrutide different from other GLP-1 research peptides?

Most incretin research peptides engage one receptor (GLP-1) or two (GLP-1 + GIP). Retatrutide adds glucagon-receptor agonism, making it a single-molecule triple agonist — the reason it is studied as a distinct reference standard.

Is retatrutide a GLP-1 agonist?

Retatrutide agonises the GLP-1 receptor, but it is not only a GLP-1 agonist — it also engages the GIP and glucagon receptors, which is why it is classed as a triple agonist rather than a single-incretin compound.

How does retatrutide compare to tirzepatide?

Tirzepatide is a dual agonist of the GLP-1 and GIP receptors. Retatrutide adds a third target, the glucagon receptor, making it a triple agonist. Sova supplies retatrutide for research use and does not sell tirzepatide.

What is the molecular weight of retatrutide?

Retatrutide has a molecular weight of 4731.29 g/mol and the molecular formula C₂₂₆H₃₅₆N₆₄O₆₉. Its identity is confirmed by mass spectrometry against this mass on every batch.

What retatrutide strengths does Sova stock?

Retatrutide is available in 10 mg, 20 mg and 30 mg lyophilised vials, each with its own batch code and Certificate of Analysis.

How is Sova retatrutide verified?

Every batch is analysed by reverse-phase HPLC for purity and ESI mass spectrometry for identity. A batch-linked Certificate of Analysis is supplied and can be verified from the batch code on the vial.

How should retatrutide be stored?

Store the lyophilised powder at or below −20 °C, protected from light. Once reconstituted with bacteriostatic water, keep at 2–8 °C and use within 28 days. Handling guidance only — not usage instructions.