Growth Hormone · Long-R3 growth factor
IGF-1 LR3 1mg
IGF-1 LR3 supplied as a lyophilised powder for reconstitution. Reference-grade purity, mass-spec confirmed identity, and a batch-linked Certificate of Analysis with every order.
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1 vial
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3+ vials
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−18%
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CoA-match guarantee — every vial matches its batch Certificate of Analysis, or your money back.
About the compound
What is IGF-1 LR3?
IGF-1 LR3, also called Long-R3 IGF-1, is an 83-amino-acid analogue of insulin-like growth factor 1. It differs from native IGF-1 by an arginine substitution at position 3 and a 13-residue N-terminal peptide extension. With CAS number 946870-92-4 and a molecular weight of approximately 9117.6, Sova supplies IGF-1 LR3 UK as a 1mg research vial for laboratory investigation.
These two structural modifications reduce the analogue's affinity for the IGF binding proteins that normally sequester native IGF-1. With less binding-protein capture, a greater fraction remains unbound in experimental systems, and the molecule exhibits a substantially longer functional half-life. It retains the capacity to interact with the IGF-1 receptor, the tyrosine-kinase receptor central to the growth-factor signalling cascades studied in cell biology.
In the research literature IGF-1 LR3 is used chiefly in cell-growth and growth-factor studies. Because of its extended half-life and reduced binding-protein interference, it is a common supplement in mammalian cell-culture media, where investigators examine proliferation, differentiation and receptor-signalling responses. It also features in comparative studies of IGF analogues and in downstream PI3K and MAPK pathway research.
Every batch of Sova IGF-1 LR3 is characterised by reverse-phase HPLC and ESI mass spectrometry, with the outcomes recorded on a batch-linked Certificate of Analysis. The lyophilised powder should be stored sealed, frozen and protected from light and moisture, and kept refrigerated once reconstituted for research. This product is supplied strictly for laboratory research use only, not for human or veterinary use.
Specification
Read the vial.
- Compound
- IGF-1 LR3
- CAS number
- 946870-92-4
- Molecular weight
- 9117.60 g/mol
- Purity (HPLC)
- 98.5%
- Identity
- Confirmed by mass spectrometry
- Form
- Lyophilised powder, sterile-filtered
- Storage
- Store lyophilised at ≤ −20 °C, protected from light. Reconstituted: 2–8 °C, use within 28 days.
- Tested by
- Independent UK laboratory
- Batch
- SVA-0432
Reconstitution guidance
Handled like a lab reagent.
Reconstitute with bacteriostatic water. Draw slowly against the vial wall — do not agitate. Swirl gently until fully dissolved. Store reconstituted vials at 2–8 °C and use within 28 days. Full protocol on the Certificate of Analysis.
Example dilutions · 1 mg vial
| BAC water | Concentration | Per 0.05 ml |
|---|---|---|
| 1.0 ml | 1 mg / ml | 0.05 mg |
| 2.0 ml | 0.50 mg / ml | 0.03 mg |
| 3.0 ml | 0.33 mg / ml | 0.02 mg |
| 5.0 ml | 0.20 mg / ml | 0.01 mg |
Concentration reference only — not a dosing schedule.
FAQ
IGF-1 LR3, answered.
What is IGF-1 LR3?
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IGF-1 LR3 (Long-R3 IGF-1) is an 83-amino-acid analogue of insulin-like growth factor 1, modified with an arginine at position 3 and an N-terminal extension. Carrying CAS 946870-92-4 and a molecular weight near 9117.6, it is supplied as a 1mg research vial.
Is IGF-1 LR3 legal to buy in the UK?
+
IGF-1 LR3 is offered in the UK solely as a research chemical for laboratory use. It is not a medicine, supplement or food product, and it is not intended for human or veterinary use. Researchers are responsible for compliant handling and storage within a suitable research facility.
What is IGF-1 LR3 studied for?
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In research IGF-1 LR3 is studied in cell-growth and growth-factor contexts. Its extended half-life and reduced binding-protein interaction make it a frequent additive in mammalian cell-culture systems, where scientists investigate proliferation, differentiation and IGF-1 receptor signalling, as well as comparisons between IGF analogues.
How is Sova's IGF-1 LR3 verified?
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Sova analyses each IGF-1 LR3 batch by reverse-phase HPLC to assess identity and purity and by ESI mass spectrometry to confirm the molecular weight. These results are compiled into a batch-linked Certificate of Analysis, so every vial can be matched to its own analytical record.
How should IGF-1 LR3 be stored?
+
Store the lyophilised IGF-1 LR3 sealed and frozen, protected from light and moisture. Once reconstituted for research, keep it refrigerated and avoid repeated freeze-thaw cycles, which can degrade larger peptides. Handling on ice during preparation helps preserve its integrity.
How does IGF-1 LR3 differ from native IGF-1?
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IGF-1 LR3 carries two changes: an arginine substituted at position 3 and an added 13-amino-acid N-terminal sequence. Together these lower its affinity for IGF binding proteins, leaving more of the analogue unbound and giving it a markedly longer half-life than native IGF-1 in research models.
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