Healing & Recovery · Thymosin β-4 active fragment
TB-500 5mg
TB-500 supplied as a lyophilised powder for reconstitution. Reference-grade purity, mass-spec confirmed identity, and a batch-linked Certificate of Analysis with every order.
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1 vial
Base
3+ vials
−10%
6+ vials
−18%
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CoA-match guarantee — every vial matches its batch Certificate of Analysis, or your money back.
About the compound
What is TB-500?
TB-500 is a synthetic peptide corresponding to the biologically active region of thymosin beta-4, a naturally occurring protein involved in actin regulation and cell migration. It carries CAS number 77591-33-4 and a molecular weight of 4963.44. Rather than reproducing the full parent protein, TB-500 represents the short fragment identified in research as central to thymosin beta-4's actin-binding activity, which makes it a common laboratory reference material.
Mechanistically, TB-500 is examined in the research literature for its interaction with G-actin, the monomeric form of actin, which it is reported to bind and sequester. Through this actin-regulating behaviour, studies explore its influence on cell migration, cytoskeletal remodelling and angiogenesis in experimental models. These proposed pathways underpin much of the interest in thymosin beta-4 biology and remain subjects of continued laboratory characterisation rather than established outcomes.
Across tissue-repair and recovery-focused research, TB-500 is studied for its reported role in cell-migration and wound-model systems, and it is frequently paired with BPC-157 in comparative experimental designs. Laboratories sourcing TB-500 UK stock generally reference this published body of work when planning controlled studies. The two peptides are distinct in structure and mechanism despite often appearing together throughout the research literature.
Sova Peptides supplies TB-500 as a lyophilised research material for in-vitro and laboratory study by qualified researchers. Every batch is characterised by reverse-phase HPLC and ESI mass spectrometry, with a batch-linked Certificate of Analysis provided for verification against the expected molecular weight. Standard lyophilised-peptide storage and handling apply throughout. This product is supplied strictly for laboratory research use only and is not for human or veterinary use.
Specification
Read the vial.
- Compound
- TB-500
- CAS number
- 77591-33-4
- Molecular weight
- 4963.44 g/mol
- Purity (HPLC)
- 98.9%
- Identity
- Confirmed by mass spectrometry
- Form
- Lyophilised powder, sterile-filtered
- Storage
- Store lyophilised at ≤ −20 °C, protected from light. Reconstituted: 2–8 °C, use within 28 days.
- Tested by
- Independent UK laboratory
- Batch
- SVA-0403
Reconstitution guidance
Handled like a lab reagent.
Reconstitute with bacteriostatic water. Draw slowly against the vial wall — do not agitate. Swirl gently until fully dissolved. Store reconstituted vials at 2–8 °C and use within 28 days. Full protocol on the Certificate of Analysis.
Example dilutions · 5 mg vial
| BAC water | Concentration | Per 0.05 ml |
|---|---|---|
| 1.0 ml | 5 mg / ml | 0.25 mg |
| 2.0 ml | 2.50 mg / ml | 0.13 mg |
| 3.0 ml | 1.67 mg / ml | 0.08 mg |
| 5.0 ml | 1 mg / ml | 0.05 mg |
Concentration reference only — not a dosing schedule.
FAQ
TB-500, answered.
What is TB-500?
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TB-500 is a synthetic peptide representing the active region of thymosin beta-4, a naturally occurring protein linked to actin regulation and cell migration. It carries CAS number 77591-33-4 and a molecular weight of 4963.44, and is used as a reference material in laboratory research.
Is TB-500 legal to buy in the UK?
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TB-500 is not a licensed medicine in the UK and is supplied strictly as a research chemical for laboratory use only. Purchase and supply for that purpose are permitted when it is not marketed for human consumption, with compliant handling the responsibility of the purchasing researcher or institution.
What is TB-500 studied for?
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TB-500 is investigated in the research literature for its reported influence on cell migration, cytoskeletal remodelling and angiogenesis within tissue-repair and wound-model systems. This work is exploratory and carried out in laboratory or animal models, and does not establish any effect in humans.
How is Sova's TB-500 verified?
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Each batch of Sova's TB-500 is analysed by reverse-phase HPLC for identity and by ESI mass spectrometry to confirm its molecular weight against the expected 4963.44. A batch-linked Certificate of Analysis accompanies every lot so researchers can verify the exact material they receive.
How should TB-500 be stored?
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Lyophilised TB-500 is generally kept cold and shielded from light, refrigerated for shorter periods and frozen for longer-term storage. After reconstitution for research, solutions are typically refrigerated and used within a limited timeframe, with containers sealed against moisture and repeated freeze-thaw cycling.
Why is TB-500 often paired with BPC-157 in research?
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TB-500 is often studied alongside BPC-157 because the two act through different reported mechanisms, TB-500 through actin regulation and cell migration and BPC-157 through angiogenic and growth-factor pathways. Researchers sometimes examine them in parallel, though each is a separate compound.